35 genetic interactions and 41 correlations retrieved

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Genetic interactions
Correlations

Negative genetic interactions

Query gene Array gene SGA score p-value
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YOR054C - VHS3, YOR29-05
Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
-0.32 3.4e-10
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YNL064C - YDJ1, HSP40, MAS5
Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family
-0.31 0.0e+00
YMR139W - RIM11, MDS1, GSK3
Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
-0.30 6.7e-07
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YMR139W - RIM11, MDS1, GSK3
Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication
-0.30 6.7e-07
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YJL106W - IME2, SME1
Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
-0.29 1.5e-04
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YLR429W - CRN1
Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly
-0.27 2.5e-03
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YJR054W - KCH1, ERM6
Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication
-0.26 2.8e-03
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YMR205C - PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
-0.25 2.4e-08
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YMR003W - AIM34
Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss
-0.25 3.5e-07
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YGR122W -
Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
-0.25 9.4e-08
YOR275C - RIM20
Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
-0.24 5.3e-03
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YOL013W-A - , YOL013W-B
Putative protein of unknown function; identified by SAGE
-0.24 3.5e-10
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YOR275C - RIM20
Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
-0.24 5.3e-03
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YBR177C - EHT1
Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication
-0.23 3.8e-02
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YGL071W - AFT1, RCS1
Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
-0.22 6.8e-05
YBR171W - SEC66, SEC71, HSS1
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
-0.22 1.5e-04
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YBR171W - SEC66, SEC71, HSS1
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
-0.22 1.5e-04
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YLR261C - VPS63
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
-0.20 1.4e-02
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YPL261C -
Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W
-0.20 2.9e-02
YLR190W - MMR1
Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
-0.19 4.8e-02
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YLR190W - MMR1
Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
-0.19 4.8e-02
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YOR327C - SNC2
Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication
-0.18 4.1e-02
YJL187C - SWE1, WEE1
Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
-0.17 2.0e-02
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YJL187C - SWE1, WEE1
Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
-0.17 2.0e-02
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YLR315W - NKP2
Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
-0.17 8.8e-05
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YMR052C-A -
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
-0.17 1.4e-02

Positive genetic interactions

Query gene Array gene SGA score p-value
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YLL047W -
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
0.22 7.3e-29
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YLR372W - SUR4, APA1, VBM1, SRE1, ELO3
Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
0.20 1.5e-07
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YMR164C - MSS11
Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals
0.20 8.2e-04
YMR164C - MSS11
Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.20 8.2e-04
YLR314C - cdc3-3
Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.17 1.4e-21
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YLR012C -
Putative protein of unknown function; YLR012C is not an essential gene
0.17 8.3e-03
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YNL076W - MKS1, LYS80
Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling
0.15 2.4e-02
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YKL109W - HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.14 6.5e-04
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YBL007C - SLA1
Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
0.12 3.0e-02

Correlations

Gene 1 Gene 2 Correlation
YKR018C - YKR018C
Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.201
YNR028W - CPR8
Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; CPR8 has a paralog, CPR4, that arose from the whole genome duplication
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.194
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YPR200C - ARR2, ACR2
Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p
0.157
YGL260W - YGL260W
Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.151
YFL013C - IES1
Subunit of the INO80 chromatin remodeling complex
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.146
YDR257C - RKM4, SET7, RMS1
Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.137
YIL047C - SYG1
Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.134
YPL198W - RPL7B, YL8, L7B, L6B, L30, rp11
Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.132
YER092W - IES5
Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.132
YOR342C - YOR342C
Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.131
YMR266W - RSN1
Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.130
YOR228C - YOR228C
Protein of unknown function, localized to the mitochondrial outer membrane
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.129
YEL051W - VMA8
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.125
YNL101W - AVT4
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.124
YML094W - GIM5, PFD5
Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.122
YFR020W - YFR020W
Protein of unknown function; mRNA identified as translated by ribosome profiling data
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.119
YER184C - YER184C
Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.117
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YPR138C - MEP3
Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease; MEP3 has a paralog, MEP1, that arose from the whole genome duplication
0.116
YKL087C - CYT2, CC1HL
Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.115
YGL133W - ITC1
Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex; ITC1 has a paralog, YPL216W, that arose from the whole genome duplication
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.114
YBR025C - OLA1
P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.112
YHR207C - SET5
Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.110
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YPR173C - VPS4, DID6, VPT10, VPL4, GRD13, END13, CSC1
AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.110
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YPR012W - YPR012W
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
0.108
YDR271C - YDR271C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.107
YML005W - TRM12, TYW2
S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.107
YML087C - AIM33
Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.106
YDR326C - YSP2
Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.104
YHR093W - AHT1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.104
YLR300W - EXG1, BGL1
Major exo-1,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a paralog, SPR1, that arose from the whole genome duplication
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.104
YIR037W - HYR1, ORP1, GPX3
Thiol peroxidase; functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor; HYR1 has a paralog, GPX1, that arose from the whole genome duplication
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.103
YFL055W - AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.102
YGR126W - YGR126W
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.102
YML129C - COX14
Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.102
YOL013C - HRD1, DER3
Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.101
YPR005C - HAL1
Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.101
YER002W - NOP16
Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.101
YKL046C - DCW1
Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.101
YLL019C - KNS1, L124
Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.101
YIL016W - SNL1
Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
0.100
YPR009W - SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication
YPR157W - YPR157W
Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; TDA6 has a paralog, VPS62, that arose from the whole genome duplication
0.100