4 genetic interactions and 112 correlations retrieved

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Genetic interactions
Correlations

Negative genetic interactions

Query gene Array gene SGA score p-value
YMR227C - taf7-ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YBR194W - AIM4, SOY1
Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress
-0.26 1.3e-09
YMR227C - taf7-ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YLR193C - UPS1
Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
-0.24 4.4e-05
YMR227C - taf7-ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YGR281W - YOR1, YRS1
Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)
-0.21 5.1e-03
YMR227C - taf7-ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YLR452C - SST2
GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
-0.19 1.6e-03

Correlations

Gene 1 Gene 2 Correlation
YLL003W_tsq475 - sfi1_3
Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.301
YDL217C_tsq714 - tim22_19
Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.248
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YNL291C - MID1
N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.246
YBR087W_tsq887 - rfc5_1
Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.229
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YMR233W - TRI1
Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication
0.217
YER096W - SHC1
Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.212
YKL103C - LAP4, LAP4, API, YSC1
Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.209
YBR016W - YBR016W
Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.205
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YPL004C - LSP1
Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.197
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YMR243C - ZRC1, OSR1
Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication
0.194
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YNL253W - TEX1
Protein involved in mRNA export, component of the transcription export (TREX) complex
0.194
YDR072C - IPT1, KTI6, SYR4
Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.190
YDR225W - HTA1, SPT11, H2A1
Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.190
YKR044W - UIP5
Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.180
YDR153C - ENT5
Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.177
YHR044C - DOG1
2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.175
YBR094W - PBY1
Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.175
YKL188C - PXA2, PAT1
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.167
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YNL010W - YNL010W
Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
0.167
YDR314C - RAD34
Protein involved in nucleotide excision repair (NER); homologous to RAD4
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.165
YLR312C - QNQ1, QNQ1
Putative protein of unknown function
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.165
YMR161W - HLJ1
Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.165
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YNL275W - BOR1
Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1
0.164
YDR438W - THI74
Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.159
YIL011W - TIR3, YIB1
Cell wall mannoprotein; member of Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; TIR3 has a paralog, TIR2, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.156
YML081C-A - ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.153
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YPL058C - PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
0.152
YGR027C - RPS25A, S25e, rp45, YS23, S31A, S25A, RPS31A
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.148
YMR092C - AIP1
Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.147
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YNL231C - PDR16, SFH3
Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress
0.146
YML074C - FPR3, NPI46
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; FPR3 has a paralog, FPR4, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.146
YLR113W - HOG1, SSK3
Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.145
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YPR062W - FCY1, yCD
Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
0.145
YER037W - PHM8
Lysophosphatidic acid (LPA) phosphatase; involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p; PHM8 has a paralog, SDT1, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.145
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YOR306C - MCH5
Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
0.142
YLR042C - YLR042C
Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.141
YDL178W - DLD2, AIP2
D-lactate dehydrogenase, located in the mitochondrial matrix
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.140
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YPL274W - SAM3
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
0.140
YDR145W_tsq515 - taf12_W486stop, TafII61, TafII68, TAF68, TAF61
Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.140
YDR512C - EMI1
Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.140
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YPL046C - ELC1, elongin C
Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair
0.139
YDL246C - SOR2
Protein of unknown function; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase; computational analysis of large-scale protein-protein interaction data also suggests a role in fructose or mannose metabolism
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.138
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YOL068C - HST1
NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication
0.138
YJL192C - SOP4
ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.136
YMR033W_tsq495 - arp9_1, RSC12, SWP59
Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.135
YIL044C - AGE2, SAT2
ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.135
YML128C - MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.133
YML038C - YMD8
Putative nucleotide sugar transporter, has similarity to Vrg4p
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.132
YGR125W - YGR125W
Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.131
YBR198C_tsq509 - taf5_3, TafII90, TAF90
Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.129
YDL028C_tsq169 - mps1_417, PAC8, RPK1
Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.129
YDL066W - IDP1
Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.128
YEL034W_tsq736 - hyp2_1, eIF-5A, eIF5A, TIF51A
Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.126
YMR086W - YMR086W
Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation, controls eisosome length and shape; diffusely distributed, forms heterogeneous patches at plasma membrane in small buds, also found in medium and large buds; expression repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes; SEG1 has a paralog, SEG2, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.126
YDL192W - ARF1
ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.124
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YOR250C_damp - CLP1_damp
Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation
0.123
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YPL195W - APL5, YKS4
Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
0.123
YHR155W - YSP1
Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.123
YGL112C_tsq608 - taf6_ts, TafII60, TAF60
Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.122
YLR005W_tsq752 - ssl1_T242I
Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.121
YIR010W_tsq436 - dsn1_8
Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.120
YJL093C - TOK1, YPK1, YORK, YKC1, DUK1
Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.120
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YMR235C_tsq172 - rna1_S116F
GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
0.120
YKR008W_tsq498 - rsc4_2
Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.120
YDL245C - HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.119
YBR260C - RGD1
GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.119
YIL156W - UBP7
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP7 has a paralog, UBP11, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.119
YMR048W - CSM3
Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.119
YBR068C - BAP2
High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.118
YGL126W - SCS3, FIT2B
Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.117
YBR007C - DSF2
Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.117
YKL056C - TMA19, MMI1, RBF18
Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.117
YJL030W - MAD2
Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.115
YHR114W - BZZ1, LSB7
SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.114
YBR111W-A - SUS1
Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.114
YBR060C_tsq331 - orc2_3, SIR5, RRR1
Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.112
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YOR264W - DSE3
Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.112
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YPL270W - MDL2
Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
0.112
YLR373C - VID22
Glycosylated integral membrane protein localized to plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles; VID22 has a paralog, ENV11, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.112
YHR046C - INM1
Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.111
YDR088C_tsq656 - slu7_ts1, SLT17
RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.111
YGR140W_tsq133 - cbf2_1, CSL5, NDC10, CTF14, CEP2, CBF3A
Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.110
YGR230W - BNS1
Protein of unknown function; overexpression bypasses need for Spo12p, but not required for meiosis; BNS1 has a paralog, SPO12, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.110
YMR075W - RCO1
Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.109
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YOR355W - GDS1
Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.109
YGL224C - SDT1, SSM1
Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; SDT1 has a paralog, PHM8, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.107
YKR062W_tsq692 - tfa2_45
TFIIE small subunit, involved in RNA polymerase II transcription initiation
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.107
YLL010C - PSR1
Plasma membrane associated protein phosphatase; involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p; PSR1 has a paralog, PSR2, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.107
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YNR022C - MRPL50
Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.107
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YNL255C - GIS2
Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
0.106
YGR127W - YGR127W
Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.105
YJL151C - SNA3
Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.105
YCL048W - SPS22
Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.105
YIL150C_tsq110 - mcm10_1, DNA43
Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.104
YER035W - EDC2
RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog, EDC1, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.104
YBL031W - SHE1
Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.103
YLR126C - YLR126C
Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.103
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YOR120W - GCY1, GCY
Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication
0.103
YER177W - BMH1, APR6
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; BMH1 has a paralog, BMH2, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.103
YML130C_tsq203 - ero1_1
Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.103
YMR130W - YMR130W
Putative protein of unknown function; YMR130W is not an essential gene
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.103
YCL044C - MGR1
Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.102
YAR029W - YAR029W
Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.102
YKL193C_tsq572 - sds22_5, EGP1
Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.102
YDL036C - PUS9
Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog, RIB2, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.101
YKL217W - JEN1
Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.101
YBR238C - YBR238C
Mitochondrial membrane protein; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span; YBR238C has a paralog, RMD9, that arose from the whole genome duplication
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.100
YDR052C_tsq163 - dbf4_3, DNA52, LSD7
Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.100
YJL187C - SWE1, WEE1
Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.100
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YNR031C - SSK2
MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; SSK2 has a paralog, SSK22, that arose from the whole genome duplication
0.100
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YOR184W - SER1, ADE9
3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.100
YMR227C_tsq638 - taf7_ts1, TafII67, TAF67
TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YPL241C - CIN2
GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.100