160 genetic interactions and 72 correlations retrieved

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Genetic interactions
Correlations

Negative genetic interactions

Query gene Array gene SGA score p-value
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL119W - NCS2, TUC2
Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
-0.48 7.9e-18
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR023C - EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
-0.48 5.6e-20
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR025W - HST3
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
-0.44 8.0e-17
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YIL008W - URM1
Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response
-0.44 1.6e-17
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YHR111W - UBA4, YHR1
Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
-0.43 1.4e-23
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR194W - AIM4, SOY1
Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress
-0.43 1.3e-13
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YFR040W - SAP155
Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress; SAP155 has a paralog, SAP4, that arose from the whole genome duplication
-0.42 2.7e-10
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR485C - VPS72, SWC2
Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting
-0.41 1.4e-23
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YJL168C - SET2, KMT3, EZL1
Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
-0.41 2.3e-15
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YJL169W -
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
-0.40 2.4e-15
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YAL011W - SWC3, SWC1
Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
-0.37 6.0e-07
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YJL124C - LSM1, SPB8
Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
-0.37 1.1e-13
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR167C - MET16
3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
-0.37 2.9e-07
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR179C - HDA3, PLO1
Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p
-0.36 7.5e-10
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGL043W - DST1, SII, S-II, TFIIS, P37, PPR2
General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress
-0.35 4.4e-10
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YCL061C - MRC1, YCL060C
S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres
-0.35 1.9e-10
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGR270W - YTA7
Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p
-0.35 1.3e-07
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YCR077C - PAT1, MRT1
Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
-0.34 1.4e-07
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YLR384C - IKI3, KTI7, TOT1, ELP1
Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
-0.34 1.5e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR237W - BCH1
Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication
-0.34 1.1e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YKL110C - KTI12, TOT4
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
-0.33 2.3e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR231C - SWC5, AOR1
Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
-0.33 6.8e-09
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL086C - ELP3, KAT9, KTI8, TOT3, HPA1
Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
-0.32 2.6e-06
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBL051C - PIN4, MDT1
Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
-0.32 7.0e-09
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR038C - HIR2, SPT1
Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
-0.32 1.6e-07
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL120C -
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
-0.32 1.8e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR290W - , SWS1
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
-0.31 4.0e-07
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGL211W - NCS6, TUC1, YGL210W-A
Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
-0.31 1.4e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNR010W - CSE2, MED9
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity
-0.31 1.2e-12
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR070W - MED1
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
-0.31 1.4e-11
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YLR085C - ARP6
Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
-0.30 1.9e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YJR054W - KCH1, ERM6
Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication
-0.29 3.9e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR289C - RTT103
Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
-0.29 1.2e-12
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGR122W -
Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
-0.28 4.5e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YLR004C - THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
-0.28 1.4e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR200W - BEM1, SRO1
Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
-0.28 2.5e-06
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBL008W - HIR1
Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
-0.27 3.1e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGR092W - DBF2
Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis; DBF2 has a paralog, DBF20, that arose from the whole genome duplication
-0.27 6.9e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOL004W - SIN3, UME4, SDS16, SDI1, RPD1, GAM2, CPE1
Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
-0.27 3.3e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR334W - SWR1
Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
-0.26 3.4e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR030W - DFG16, ZRG12, ECM41
Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
-0.26 1.0e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR032W - SRO7, SOP1, SNI1
Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
-0.26 1.0e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL157W - TGS1
Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
-0.26 2.8e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR118W - TEF2, eEF1A
Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
-0.25 3.0e-23
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGL151W - NUT1, MED5
Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
-0.24 1.8e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YKL074C - MUD2
Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
-0.24 1.9e-52
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YKR024C - DBP7
Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions
-0.24 4.1e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YKL113C - RAD27, FEN1, RTH1, ERC11
5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
-0.24 1.4e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL260W -
Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress
-0.24 2.2e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR057W - BRR1
snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed
-0.24 4.5e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YLR048W - RPS0B, S2, S0B, YST2, NAB1B
Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
-0.24 1.3e-56
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YHR059W - FYV4
Protein of unknown function, required for survival upon exposure to K1 killer toxin
-0.23 1.2e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR075W - RCO1
Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
-0.23 1.3e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGL016W - KAP122, PDR6
Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance
-0.23 1.0e-06
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL102C -
Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4
-0.23 9.5e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YIL084C - SDS3
Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
-0.23 4.6e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YJR140C - HIR3, HPC1
Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein
-0.23 2.8e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR044W - IOC4
Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
-0.23 4.1e-09
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL012W - SPO1
Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B
-0.23 9.8e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR061C - JID1
Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
-0.22 4.4e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGL045W - RIM8, ART9, YGL046W, PAL3
Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
-0.22 1.7e-29
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR031W-A -
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
-0.22 6.6e-06
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDL081C - RPP1A, RPLA1
Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
-0.22 7.5e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL101W - ELP4, KTI9, TOT7, HAP1
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
-0.21 1.3e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR149C -
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth
-0.21 1.8e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL139C - UME1, WTM3
Negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication
-0.21 1.6e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR275C - RIM20
Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
-0.21 3.7e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YLR014C - PPR1
Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
-0.21 4.4e-15
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGR200C - ELP2, KTI3, TOT2
Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
-0.21 4.2e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YJL115W - ASF1, CIA1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
-0.21 1.5e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR184C - ATC1, LIC4
Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress
-0.20 1.7e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YHR203C - RPS4B, S4e, rp5, YS6, S7B, S4B
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
-0.20 4.1e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YFL051C -
Putative protein of unknown function; YFL051C is not an essential gene
-0.20 9.9e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGL031C - RPL24A, L24e, rp29, YL21, L30A, L24A, RPL30A
Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication
-0.20 6.6e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL090C - RPS6A, S6e, rp9, YS4, S6A, S10A
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication
-0.19 4.0e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YHR041C - SRB2, MED20, HRS2
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
-0.19 7.3e-09
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL184C - MRN1, PTR69
RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation
-0.19 6.0e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR066W - UBA3
Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
-0.19 2.8e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL064C - YDJ1, HSP40, MAS5
Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family
-0.19 2.9e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YKL184W - SPE1, SPE10, ORD1
Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
-0.19 2.6e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR075C-A -
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W
-0.18 3.2e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YJL082W - IML2
Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication
-0.18 6.9e-22
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YLR200W - YKE2, PFD6, GIM1
Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
-0.18 7.6e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR048W - RPS11B, S17, rp41B, YS12, S18B, S11B
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
-0.18 1.1e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR150W - NUM1, PAC12
Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
-0.18 2.3e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YHL023C - NPR3, RMD11
Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair
-0.18 4.0e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR274W - CHK1
Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
-0.17 9.1e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL085W - MKT1
Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress
-0.17 3.0e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOL090W - MSH2, PMS5
Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP
-0.17 9.2e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL239W - YAR1
Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
-0.17 6.3e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YLR095C - IOC2
Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
-0.17 5.2e-32
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR246W - RRT2, DPH7, ERE1
Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
-0.17 1.4e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR378C - LSM6
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
-0.17 6.6e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBL009W - ALK2
Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
-0.17 1.7e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR120C - CLB5
B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog, CLB6, that arose from the whole genome duplication
-0.17 7.7e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR086C - IST2
Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
-0.17 2.2e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR335W - MSN5, STE21, KAP142
Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
-0.17 7.8e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YER074W - RPS24A, S24e, S24A, RPS24EA
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
-0.16 2.3e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL091W - NST1
Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
-0.16 3.4e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR183W - FYV12
Protein of unknown function, required for survival upon exposure to K1 killer toxin
-0.16 2.3e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR314W -
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
-0.16 1.8e-02

Positive genetic interactions

Query gene Array gene SGA score p-value
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YCR063W - BUD31, CWC14
Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.47 6.8e-07
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR044C - TCM62
Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
0.29 3.6e-07
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGL213C - SKI8, REC103
Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype
0.23 3.9e-20
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YKL176C - LST4
Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.22 1.8e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGR281W - YOR1, YRS1
Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)
0.20 1.1e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDL020C - RPN4, UFD5, SON1
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.19 3.0e-06
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL081C - SWS2
Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.19 8.4e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL069C - BTS1
Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
0.19 1.0e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL041C - COG6, SEC37, COD2
Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.19 8.5e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOL006C - TOP1, MAK17, MAK1
Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
0.19 2.2e-07
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL106C - SSE1, MSI3, LPG3
ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication
0.18 1.8e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR074C - TKL1
Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.18 4.8e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL080C -
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.18 1.7e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR131W - CCZ1, CVT16
Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.17 1.1e-07
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDL006W - PTC1, TPD1, KCS2, CWH47
Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation
0.17 7.6e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YCR044C - PER1, COS16
Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1
0.17 2.5e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR054C - VHS3, YOR29-05
Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
0.17 1.3e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL051W - COG5, COD4, API4
Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.17 7.6e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR224W -
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
0.17 3.3e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGL054C - ERV14
COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication
0.17 1.2e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR144C - MKC7, YPS2
GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog, YPS1, that arose from the whole genome duplication
0.17 2.8e-112
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR131C -
Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress
0.16 2.4e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YER111C - SWI4, ART1
DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p
0.16 1.1e-06
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR344C - TYE7, SGC1
Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
0.16 6.3e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR027W - STI1
Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop
0.16 3.1e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YHR081W - LRP1, RRP47, YC1D
Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
0.16 1.4e-12
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YCR086W - CSM1
Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.16 8.4e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR135W - CTF4, POB1, CHL15
Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
0.16 4.5e-13
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDL192W - ARF1
ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.16 1.1e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR315C - IPK1, GSL1
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.15 5.9e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR082C - UBC4
Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.15 1.2e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR189W - SKI3, SKI5
Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.15 1.6e-09
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YHL034C - SBP1, SSB1, SSBR1
Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
0.15 5.2e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR463W - STP1, SSY2, BAP1
Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication
0.15 2.6e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR148C - KGD2
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.15 6.9e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL141W - AAH1
Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
0.14 1.4e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGL244W - RTF1, CSL3
Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
0.14 3.4e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YER139C - RTR1
CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication
0.14 2.6e-06
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL205C -
Hypothetical protein; deletion of locus affects telomere length
0.14 1.5e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR040W - GLO4
Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that arose from the whole genome duplication
0.14 2.4e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDL177C -
Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.14 1.1e-09
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YKR082W - NUP133, RAT3
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133
0.14 3.5e-06
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR389W - SAC7
GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
0.13 6.8e-17
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR216C - RUD3, GRP1
Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1
0.13 4.2e-04
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL056W - OCA2
Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.13 4.6e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YJL036W - SNX4, ATG24, CVT13
Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p
0.13 5.1e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR255W - MTC4
Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.13 1.8e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR085W - OST3
Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.13 6.9e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDL077C - VAM6, VPS39, VPL22, VPL18, CVT4
Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.13 1.7e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL150W -
Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.13 1.6e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDR072C - IPT1, KTI6, SYR4
Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.12 1.7e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YCL055W - KAR4
Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
0.12 3.2e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL152W - RRD2, YPA2
Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress
0.12 3.3e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YDL013W - SLX5, ULS2, HEX3
Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers
0.12 2.2e-05
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YKR007W - MEH1, GSE2, EGO1
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.12 2.1e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YGL212W - VAM7, VPL24, VPS43
Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.12 8.6e-03
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YAR002W - NUP60
FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153
0.12 1.3e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL144W - POC4, DMP1, PBA4
Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.12 4.3e-02
YML114C - taf8-7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YLR087C - CSF1
Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.12 2.2e-04

Correlations

Gene 1 Gene 2 Correlation
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR070W - MED1
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.299
YDR145W_tsq515 - taf12_W486stop, TafII61, TafII68, TAF68, TAF61
Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.287
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL215W - IES2
Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.263
YLR005W_tsq752 - ssl1_T242I
Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.229
YGL127C - SOH1, MED31
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.204
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR178W_tsq500 - prp4_1, RNA4
Splicing factor, component of the U4/U6-U5 snRNP complex
0.184
YGR270W - YTA7
Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.180
YFL001W - DEG1, HRM3, PUS3
tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.175
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR101W - SNT309, NTC25
Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p
0.171
YGR006W_tsq434 - prp18_ts
Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.170
YAL011W - SWC3, SWC1
Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.156
YIL078W_damp - THS1_damp
Threonyl-tRNA synthetase, essential cytoplasmic protein
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.153
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNR010W - CSE2, MED9
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity
0.150
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOR250C_damp - CLP1_damp
Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation
0.147
YGL112C_tsq608 - taf6_ts, TafII60, TAF60
Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.144
YJR139C - HOM6, THR6
Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.144
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR077C - VPS20, VPL10, VPT20, CHM6
Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
0.143
YGL244W - RTF1, CSL3
Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.143
YDR088C_tsq656 - slu7_ts1, SLT17
RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.141
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YNL216W_damp - RAP1_damp, TUF1, TBA1, GRF1
Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)
0.140
YBR079C_damp - RPG1_damp, TIF32
eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.137
YLR417W - VPS36, VPL11, VAC3, GRD12
Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.134
YLR298C_tsq844 - yhc1_8, U1C, U1-C
Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.131
YML094W - GIM5, PFD5
Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.130
YBR060C_tsq311 - orc2_2, SIR5, RRR1
Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.129
YHR041C - SRB2, MED20, HRS2
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.129
YDR276C - PMP3, SNA1
Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.128
YBR198C_tsq512 - taf5_15, TafII90, TAF90
Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.127
YER016W - BIM1, EB1, YEB1
Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.127
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR075W - RCO1
Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
0.126
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR165C - PAH1, SMP2
Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2
0.126
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR023C - EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
0.126
YER031C - YPT31, YPT8
Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.126
YDR181C - SAS4
Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.124
YIR005W - IST3, SNU17
Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.124
YDR037W_damp - KRS1_damp, GCD5
Lysyl-tRNA synthetase
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.122
YGR274C_tsq524 - taf1_1, KAT4, TafII145, TafII130, TAF145, TAF130
TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.122
YJR102C - VPS25, VPL12, VPT25
Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.122
YLR370C - ARC18
Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.122
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YML124C - TUB3
Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.121
YLR024C - UBR2
Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.121
YDL020C - RPN4, UFD5, SON1
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.120
YLR200W - YKE2, PFD6, GIM1
Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.120
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL055C - LGE1
Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
0.119
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR178W_tsq819 - prp4_ts, RNA4
Splicing factor, component of the U4/U6-U5 snRNP complex
0.119
YEL040W - UTR2, CRH2
Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.119
YEL003W_damp - GIM4_damp, PFD2
Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.118
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR009W - ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
0.115
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YOL135C_tsq739 - med7_163
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.115
YJR083C - ACF4
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.114
YLR085C - ARP6
Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.113
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR086W - YMR086W
Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation, controls eisosome length and shape; diffusely distributed, forms heterogeneous patches at plasma membrane in small buds, also found in medium and large buds; expression repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes; SEG1 has a paralog, SEG2, that arose from the whole genome duplication
0.112
YGR252W - GCN5, AAS104, KAT2, SWI9, ADA4
Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.112
YLR386W - VAC14
Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.110
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPR167C - MET16
3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
0.110
YDL133W - YDL133W
Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.109
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR154C - RIM13, CPL1
Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.109
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL023C - MET12
Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR
0.109
YDL074C - BRE1
E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.108
YDR121W - DPB4
Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.108
YDR485C - VPS72, SWC2
Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.108
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR033W_tsq495 - arp9_1, RSC12, SWP59
Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.108
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR063W - RIM9
Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.108
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR096W - SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.107
YLR433C - CNA1, CMP1
Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; CNA1 has a paralog, CMP2, that arose from the whole genome duplication
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.107
YDR346C - SVF1, SGI1
Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.106
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL228W_tsq420 - cet1_15, CES5
RNA 5'-triphosphatase; beta subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide; CET1 has a paralog, CTL1, that arose from the whole genome duplication
0.106
YER061C - CEM1
Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.103
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YPL181W - CTI6, RXT1
Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
0.103
YDR448W - ADA2, SWI8
Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.102
YKL033W-A - YKL033W_A
Putative protein of unknown function; similar to uncharacterized proteins from other fungi
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.101
YML114C_tsq695 - taf8_7, TafII65, TAF65
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YMR179W - SPT21
Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.101