3 genetic interactions and 128 correlations retrieved

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Genetic interactions
Correlations

Negative genetic interactions

Query gene Array gene SGA score p-value
YKR082W - NUP133, RAT3
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
-0.33 1.6e-08

Positive genetic interactions

Query gene Array gene SGA score p-value
YEL036C - ANP1, MNN8, GEM3
Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.13 8.7e-03
YPL051W - ARL3
GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.12 3.1e-02

Correlations

Gene 1 Gene 2 Correlation
YHR112C - YHR112C
Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.226
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YML107C - PML39
Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes
0.207
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJR070C - LIA1, MMD1
Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress
0.203
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR126C - YLR126C
Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.198
YDR538W - PAD1, POF1
Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.197
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YNL072W - RNH201, Rnh2A, RNH35
Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome
0.196
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YMR096W - SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.195
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YMR192W - GYL1, APP2
Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress; GYL1 has a paralog, GYP5, that arose from the whole genome duplication
0.183
YIR028W - DAL4
Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.183
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR112W - YLR112W
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.181
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YNL078W - NIS1, JIP1
Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
0.179
YBR180W - DTR1
Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.176
YBR242W - YBR242W
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene; YBR242W has a paralog, YGL101W, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.175
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YML068W - ITT1
Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
0.175
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YOR318C - YOR318C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
0.175
YJL155C - FBP26
Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.175
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPR160W - GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.172
YIR031C - DAL7, MSL2, MLS2
Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.170
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPR151C - SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.166
YDR530C - APA2
Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.165
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YOL141W - PPM2, TYW4
AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.164
YGR243W - FMP43, MPC3
Highly conserved subunit of mitochondrial pyruvate carrier; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress; FMP43 has a paralog, MPC2, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.163
YDR111C - ALT2
Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog, ALT1, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.162
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKL027W - YKL027W
tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD2 has a paralog, TCD1, that arose from the whole genome duplication
0.162
YBR240C - THI2, phoF, PHO6
Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.160
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPL035C - YPL035C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.156
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YMR210W - YMR210W
Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.155
YBR271W - YBR271W
S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.154
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YML074C - FPR3, NPI46
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; FPR3 has a paralog, FPR4, that arose from the whole genome duplication
0.153
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJL199C - MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
0.152
YCL064C - CHA1
Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.152
YJL083W - TAX4
EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.151
YJL098W - SAP185
Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.149
YGL160W - AIM14, YNO1
NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.149
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR265C - NEJ1, LIF2
Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p
0.147
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPR150W - YPR150W
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
0.146
YJL017W - YJL017W, YJL017W
Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.146
YDL189W - RBS1
Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.144
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR406C - RPL31B, L31e, YL28, L34B, L31B
Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication
0.143
YAL059W - ECM1
Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.143
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKR027W - BCH2, FMP50
Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication
0.142
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR165C - PUS5
Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability
0.142
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKR018C - YKR018C
Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.140
YGR121C - MEP1, AMT1
Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; MEP1 has a paralog, MEP3, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.140
YHR076W - PTC7
Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.139
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKL068W - NUP100, [NUP100+], NSP100
FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication
0.138
YGR109C - CLB6
B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1; CLB6 has a paralog, CLB5, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.137
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YMR153C-A - YMR153C_A
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53
0.137
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YMR199W - CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication
0.137
YJL022W - YJL022W
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.136
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJR048W - CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication
0.135
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPR194C - OPT2
Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles
0.134
YDL048C - STP4
Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has a paralog, STP3, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.132
YBR056W - YBR056W
Putative glycoside hydrolase of the mitochondrial intermembrane space
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.131
YDR134C - YDR134C
Hypothetical protein
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.131
YBR118W - TEF2, eEF1A
Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.131
YCL074W - YCL074W
Pseudogene: encodes fragment of Ty Pol protein
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.131
YGR169C - PUS6
tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.130
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YOR347C - PYK2
Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication
0.129
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR182W - SWI6, SDS11, PSL8
Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators
0.128
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKL093W - MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; MBR1 has a paralog, ISF1, that arose from the whole genome duplication
0.127
YCR060W - TAH1
Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.126
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKR041W - YKR041W
Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking
0.126
YER101C - AST2
Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.126
YGR026W - YGR026W
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.125
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJR074W - MOG1
Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.125
YGR025W - YGR025W
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.125
YGR081C - SLX9
Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.124
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJR008W - YJR008W
Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility
0.124
YGL071W - AFT1, RCS1
Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.124
YBR104W - YMC2
Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.122
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YOL014W - YOL014W
Putative protein of unknown function
0.122
YGR205W - YGR205W
ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.121
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKR053C - YSR3, LBP2
Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication
0.121
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPL182C - YPL182C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
0.121
YAL067C - SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.121
YDR210W - YDR210W
Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.120
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPL177C - CUP9
Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.120
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR390W - ECM19
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.119
YIL015C-A - YIL015C_A, YIL015C-A
Putative protein of unknown function
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.118
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR063W - YLR063W
Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.118
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR326W - YLR326W
Putative protein of unknown function, predicted to be palmitoylated
0.118
YCR015C - YCR015C
Putative protein of unknown function; YCR015C is not an essential gene
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.118
YER060W - FCY21
Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.117
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR414C - YLR414C
Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.117
YJL130C - URA2
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.117
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPR195C - YPR195C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.116
YIL140W - AXL2, SRO4, BUD10
Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.116
YIR017C - MET28
Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.115
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YOR230W - WTM1
Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
0.115
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YMR310C - YMR310C
Putative methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; not an essential gene; YMR310C has a paralog, YGR283C, that arose from the whole genome duplication
0.114
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKL026C - GPX1
Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; GPX1 has a paralog, HYR1, that arose from the whole genome duplication
0.113
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKR074W - AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss
0.113
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKR046C - PET10
Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
0.112
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPL248C - GAL4, GAL81
DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
0.112
YHR185C - PFS1, ADY1
Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.111
YIL155C - GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.111
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPL223C - GRE1
Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
0.110
YDR117C - TMA64, RBF64
Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.110
YDR540C - IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.109
YHR139C-A - YHR139C_A
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.109
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJR110W - YMR1
Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family
0.108
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR228C - ECM22
Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication
0.108
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR335W - NUP2
Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
0.108
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPL149W - ATG5, APG5
Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
0.108
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR325C - RPL38, L38e, L38
Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog
0.107
YJL121C - RPE1, POS18, EPI1
D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.106
YBL055C - YBL055C, Tat-D
3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.105
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YMR205C - PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
0.105
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YNL027W - CRZ1, TCN1, HAL8
Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.105
YAR050W - FLO1, FLO4, FLO2
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.105
YDR071C - PAA1
Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.104
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJR036C - HUL4
Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex
0.104
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YMR271C - URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication
0.104
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPL003W - ULA1, ENR2
Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
0.104
YGR187C - HGH1
Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.104
YDL200C - MGT1, MGMT
DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.103
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YNR024W - MPP6
Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes
0.103
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YOL081W - IRA2, GLC4, CCS1
GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
0.103
YDR466W - PKH3
Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.102
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR135W - SLX4
Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress
0.102
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YNL125C - ESBP6, MCH3
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
0.102
YAL005C - SSA1, YG100
ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.101
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKL038W - RGT1
Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication
0.101
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YML035C - AMD1, AMD3
AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools
0.101
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YPL156C - PRM4
Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
0.101
YDL088C - ASM4, NUP59
FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.101
YHR158C - KEL1
Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; KEL1 has a paralog, KEL2, that arose from the whole genome duplication
YJL162C - JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.100