4 genetic interactions and 47 correlations retrieved

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Genetic interactions
Correlations

Negative genetic interactions

Query gene Array gene SGA score p-value
YLR360W - VPS38, VPL17
Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
YGL114W -
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
-0.45 2.4e-24
YJL101C - GSH1
Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
YGL114W -
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
-0.35 1.1e-14
YAL041W - cdc24-4, CLS4
Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress
YGL114W -
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
-0.24 1.2e-04
YGR004W - PEX31
Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p; PEX31 has a paralog, PEX30, that arose from the whole genome duplication
YGL114W -
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
-0.17 1.8e-02

Correlations

Gene 1 Gene 2 Correlation
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGL258W - VEL1
Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C
0.179
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGL234W - ADE5,7
Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.152
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YOL085C - YOL085C
Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
0.144
YDR344C - YDR344C
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.140
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGL248W - PDE1
Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
0.139
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGR105W - VMA21
Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
0.135
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YIL138C - TPM2
Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication
0.133
YGL089C - MF(ALPHA)2
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed; MF(ALPHA)2 has a paralog, MF(ALPHA)1, that arose from the whole genome duplication
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.132
YFR020W - YFR020W
Protein of unknown function; mRNA identified as translated by ribosome profiling data
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.129
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGR124W - ASN2
Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication
0.124
YDR463W - STP1, SSY2, BAP1
Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.122
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YLR211C - YLR211C
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.122
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGR149W - YGR149W
Putative protein of unknown function; predicted to be an integal membrane protein
0.121
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGL157W - YGL157W
NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
0.119
YFL006W - YFL006W, YFL006W
Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.118
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGL203C - KEX1
Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.118
YFR024C-A - LSB3, YFR024C
Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.118
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YOL089C - HAL9
Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication
0.117
YFR032C - YFR032C
Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.115
YAL046C - AIM1
Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.114
YBR199W - KTR4
Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.113
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YJL154C - VPS35, VPT7, GRD9
Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.113
YFR015C - GSY1
Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.113
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGR136W - LSB1
Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication
0.112
YBR063C - YBR063C
Putative protein of unknown function; YBR063C is not an essential gene
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.111
YBL028C - YBL028C
Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.110
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGL166W - CUP2, ACE1
Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.110
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YHR079C-B - YHR079C_B, YHR079BC, YHR079C-B
Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
0.110
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YKL077W - YKL077W
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.109
YBL054W - TOD6, PBF1
PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.108
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YIL156W - UBP7
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP7 has a paralog, UBP11, that arose from the whole genome duplication
0.108
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YML112W - CTK3
Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress
0.107
YBR172C - SMY2
Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.107
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YIL107C - PFK26, PFK-2, PFK2
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.106
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YLR363C - NMD4
Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.106
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YHR195W - NVJ1, VAB36
Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
0.105
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YNL087W - TCB2
ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to bud; TCB2 has a paralog, TCB1, that arose from the whole genome duplication
0.105
YFR049W - YMR31
Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.104
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGR008C - STF2
Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication
0.104
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGR092W - DBF2
Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis; DBF2 has a paralog, DBF20, that arose from the whole genome duplication
0.104
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YJR019C - TES1, PTE1
Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.104
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YLR262C-A - TMA7, RBF7
Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.103
YFL049W - SWP82
Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.102
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YHR046C - INM1
Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
0.102
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YML048W - GSF2, ECM6
ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
0.102
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YML123C - PHO84, phoT
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity
0.101
YGL114W - YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YIL139C - REV7
Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.100